(Please forgive me for grammatical errors; typed with a cellphone.)
Awesome trick found through trial & error:
1.) Pick Mage. Start with Knuckleduster. Find a Scroll of Upgrade at Depth 1 and apply on Knuckleduster, then suicide at Depth 1, with only +1 Knuckleduster equipped.
2.) Choose Mage again. Look for Skeletal Remains (keep one zap charge for remains, in-case of Wraith {if Wraith appears, use wand & zap Wraith for insta-gib} ). If Knuckleduster generates from Skeletal Remains, proceed to #3; if not, start over. **Knuckleduster will be cursed; however, they maintain a +1 status. Once another Scroll of Upgrade is used on Knuckleduster, it will then be +2 & uncursed.
3.) Look for Scrolls of Upgrade at Depths 1 or 2, and apply to Knuckleduster. (At this point, should be +2 by Depth 3. And Goo can be defeated, regardless of obtaining Seed of Earthroot; and Goo is met with full HP; and you back off when !!! appears. When !!! appears, make sure there are 2 cells beween you & Goo.) Keep trolling around for another Scroll of Upgrade to use on Knuckleduster.. Always choose armor from the Sad Ghost's quest reward, so you can have a half-decent armor against Goo.
4.) Use every Scroll of Upgrade on Knuckleduster, until it hits +6. Save one Scroll of Upgrade, to throw into a Well of Transmutation & turn into a Scroll of Weapon Upgrade, to ensure you can upgrade your Knuckleduster with a random enchantment.
5.) After Goo, focus solely on finding Scrolls of Upgrade & trying to get a Scroll of Weapon Upgrade, by saving one Scroll of Upgrade at all times, in order to throw into a Well of Transmutation. At Depth-6, there will be a Shop; buy all the Potions of Healing first, then the Weightstone, and then balance your Knuckleduster for Speed. After the Weightstone is obtained, buy Seed Pouch. Scrolls are unnecessary with this path, unless you are screwed by cursed rings; then aim for Scrolls of Remove Curse.
6.) At Depths 7-9, should be a quest to find a Seed of Rotberry, or Corpse Dust. Always choose Battle wands, unless you already have a Wand of Lightning, or Wand of Firebolt. If you have at least one Battle wand, choose Non-Battle for a chance at a Wand of Slowness (it will become your favorite wand, due to it halving their movement & attack speed, which is awesome for all the bosses).
7.) Tips for Tengu: Have at least 6 Potions of Healing. If you don't have good armor, or any of the following wands (Slow, Blink, Avalanche), use pots when less than 16 hp because he can hit as high as 18, if you have bad armor. With Knuckleduster, you can attack him 2x for every one of his. With Speed-balanced Weightstone, you get 3 attacks per one of his.
8.) Due to weapon being Knuckleduster, Dwarf Monks cannot knock it out of your hand; and if balanced for speed, you attack faster than monks, and get more hits in than the Dwarf Monks, during a set amount of attack turns. Once you have at least 14 Str. & +6 knuckles, you hit as high as 22-28; the higher the upgrade & your strength, the higher the damage. Now is the ***** boss, the King of Dwarves.
9.) Tips for King of Dwarves: Carry 2 Potions of Toxic Gas, 1 Potion of Purification, or paralyze and any Slow-effect items. Use Potion of Toxic Gas before he summons on the first pedestal. The pedestal allows him to summon Undead Dwarves to fight, and the pedestals are on the left & right side of the room. If possible, throw a Seed of Dreamweed at a pedestal, and a Potion of Toxic Gas at the seed. The King of Dwarves will step on the seed & run around in toxic gas, for a long time, going below half HP; rinse & repeat as supplies last, and with paralyze potions.
10.) FIGHT AS LITTLE AS POSSIBLE at DEPTHS 23-24 OR YOU WILL WASTE A LOT OF POTIONS.
11.) SAVE AT LEAST 3 POTIONS OF INVISIBILITY FOR FINAL BOSS. AT 25TH DEPTH, USE ONE POTION PRIOR TO MOVING, TO LOCATE EYE. IGNORE FISTS. Once you locate eye, throw Potion of Paralytic Gas in Fists' direction, or start hitting the eye to generate Larvae. Larvae block fists from damaging you, thus you are best friends, once fully surrounded by Larvae & eye. Watch your HP; & use Potions of Healing, once below 20% HP, to avoid death. And only focus on hitting the eye. Once eye dies, fists die too, however, now there is a swam of Larvae (thus 3rd Potion of Invisibility). Use the potion to hide from the larvae & obtain the key, then run for the exit & win.
NOTE: This method can be used for all types; and I have won with every single Hero/ine using this method.
And it's a reliable method to win; at least 1 out of every 5, or 6 games. The only thing that varies is how you deal with situations; your choices & luck of drops. Enjoy this method.
Currently found most Challenges work with this play-style as well.
Enjoy! Courtesy of a snob, named Rob.
[Proofread by SA]